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Exame final de Neuroanatomia Descritiva e Funcional
Elaborada por Dra. Silvia Helena Cardoso
Resposta da Pergunta 2

Botulinal exotoxin, produced by Clostridium botulinum. This is a neurotoxin that acts peripherally on the autonomic nervous system. For muscle stimulation, acetylcholine must be released from the neural motor end plate of the neuron at the synapse between the neuron and the muscle to be stimulated. The acetylcholine then induces contraction of the muscle fibers.

The botulism exotoxin binds to and enters the presynaptic neuron and blocks its release of acetylcholine. This causes a flaccid paralysis, a weakening of the involved muscles.

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